Aedes-borne disease outbreaks in West Africa: A call for enhanced surveillance.

Arboviruses transmitted by Aedes mosquitoes are a growing global concern; however, there remain large gaps in surveillance of both arboviruses and their vectors in West Africa. We reviewed over 50 years of data including outbreak reports, peer-reviewed literature, and prior data compilations describing Zika, dengue, and chikungunya, and their vectors in West Africa. Large outbreaks of dengue, Zika, and chikungunya have recently occurred in the region with over 27,000 cases of Aedes-borne disease documented since 2007.

Recent arboviral outbreaks have become more concentrated in urban areas, and Aedes albopictus, a relatively new arrival in the region, has emerged as an important vector in several areas. Seroprevalence surveys suggest reported cases are a gross underestimate of the underlying arboviral disease burden.

hsa-miR-652 Primers
MPH01954	ABM	150 ul / 10 uM	EUR 121

mmu-miR-652-3p Primers
MPM01554	ABM	150 ul / 10 uM	EUR 121

mmu-miR-652-5p Primers
MPM01555	ABM	150 ul / 10 uM	EUR 121

rno-miR-652-3p Primers
MPR00801	ABM	150 ul / 10 uM	EUR 176

rno-miR-652-5p Primers
MPR00802	ABM	150 ul / 10 uM	EUR 176

hsa-miR-652 miRNA Inhibitor
MIH03348	ABM	2 x 5.0 nmol	EUR 176

mmu-miR-652 miRNA Inhibitor
MIM02429	ABM	2 x 5.0 nmol	EUR 176

rno??miR-652 miRNA Inhibitor
MIR01748	ABM	2 x 5.0 nmol	EUR 176

hsa-miR-652 miRNA Antagomir
MNH03348	ABM	2 x 5.0 nmol	EUR 329

mmu-miR-652 miRNA Antagomir
MNM02429	ABM	2 x 5.0 nmol	EUR 329

rno??miR-652 miRNA Antagomir
MNR01748	ABM	2 x 5.0 nmol	EUR 329

hsa-miR-652-3p Primers
MPH03439	ABM	150 ul / 10 uM	EUR 121

hsa-miR-652-5p Primers
MPH03440	ABM	150 ul / 10 uM	EUR 121

Zinc Finger Protein 652 (Zfp652) Antibody
abx431848-200ul	Abbexa	200 ul	EUR 286

Zinc Finger Protein 652 (ZNF652) Antibody
abx433461-200ul	Abbexa	200 ul	EUR 384

hsa-miR-652-3p miRNA Inhibitor
MIH03349	ABM	2 x 5.0 nmol	EUR 176

hsa-miR-652-5p miRNA Inhibitor
MIH03350	ABM	2 x 5.0 nmol	EUR 176

mmu-miR-652-3p miRNA Inhibitor
MIM02430	ABM	2 x 5.0 nmol	EUR 176

mmu-miR-652-5p miRNA Inhibitor
MIM02431	ABM	2 x 5.0 nmol	EUR 176

rno-miR-652-3p miRNA Inhibitor
MIR01749	ABM	2 x 5.0 nmol	EUR 176

rno-miR-652-5p miRNA Inhibitor
MIR01750	ABM	2 x 5.0 nmol	EUR 176

hsa-miR-652-3p miRNA Antagomir
MNH03349	ABM	2 x 5.0 nmol	EUR 329

hsa-miR-652-5p miRNA Antagomir
MNH03350	ABM	2 x 5.0 nmol	EUR 329

mmu-miR-652-3p miRNA Antagomir
MNM02430	ABM	2 x 5.0 nmol	EUR 329

mmu-miR-652-5p miRNA Antagomir
MNM02431	ABM	2 x 5.0 nmol	EUR 329

rno-miR-652-3p miRNA Antagomir
MNR01749	ABM	2 x 5.0 nmol	EUR 329

rno-miR-652-5p miRNA Antagomir
MNR01750	ABM	2 x 5.0 nmol	EUR 329

ROR 2 Recombinant Protein
96-652	ProSci	0.05 mg	EUR 542.75
Description: Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

DKK-3 Recombinant Protein
40-652	ProSci	2 ug	EUR 259.25
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 36.3 kDa and contains 329 amino acid residues. Due to glycosylation, Human DKK-3 migrates at an apparent molecular weight of approximately 39-49 kDa by SDS-PAGE analysis under non-reducing conditions.

G6PD Recombinant Protein
91-652	ProSci	0.05 mg	EUR 710.75
Description: Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). G6PD produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power. NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. It is notable in humans that G6PD is remarkable for its genetic diversity. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia.

Fc gamma RI Recombinant Protein
92-652	ProSci	0.05 mg	EUR 401
Description: CD64 (Fc gamma RI), one of the Fc receptors for IgG, is a membrane glycoprotein that mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. CD64 is also structurally distinct, containing an extracellular Ig-interactive region of three Ig-like domains in contrast to the two domains of the low affinity receptors Fc gamma RII and Fc gamma RIII. It is normally expressed on the surfaces of monocytes and macrophages.

Cynomolgus Her2 Protein (Thr 23-Thr 652)
VAng-1654Lsx-100g	Creative Biolabs	100 µg	EUR 875
Description: Cynomolgus Her2 is expressed in human 293 cells. (Uniprot ID: XP_005584091.2)

Cynomolgus Her2 Protein (Thr 23-Thr 652)
VAng-1654Lsx-1mg	Creative Biolabs	1 mg	EUR 5494
Description: Cynomolgus Her2 is expressed in human 293 cells. (Uniprot ID: XP_005584091.2)

Human Her2 Protein (Thr 23-Thr 652)
VAng-1711Lsx-500g	Creative Biolabs	500 µg	EUR 3349
Description: Human Her2 is expressed in human 293 cells. (Uniprot ID: P04626-1)

Human Her2 Protein (Thr 23-Thr 652)
VAng-1711Lsx-50g	Creative Biolabs	50 µg	EUR 930
Description: Human Her2 is expressed in human 293 cells. (Uniprot ID: P04626-1)

Human Her2 Protein (Thr 23-Thr 652) [Fc]
VAng-1712Lsx-100g	Creative Biolabs	100 µg	EUR 875
Description: Human Her2, Mouse IgG2a Fc tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

Human Her2 Protein (Thr 23-Thr 652) [Fc]
VAng-1712Lsx-1mg	Creative Biolabs	1 mg	EUR 5494
Description: Human Her2, Mouse IgG2a Fc tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

Human Her2 Protein (Thr 23-Thr 652) [His]
VAng-1713Lsx-100g	Creative Biolabs	100 µg	EUR 1013
Description: Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: AAA75493)

Human Her2 Protein (Thr 23-Thr 652) [His]
VAng-1713Lsx-1mg	Creative Biolabs	1 mg	EUR 6319
Description: Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: AAA75493)

Human Her2 Protein (Thr 23-Thr 652) [Strep]
VAng-1715Lsx-50g	Creative Biolabs	50 µg	EUR 1013
Description: Human Her2, Strep tag, is expressed in human 293 cells. (Uniprot ID: AAA75493)

Recombinant Mycobacterium Tuberculosis narX Protein (aa 1-652)
VAng-Yyj0532-inquire	Creative Biolabs	inquire	Ask for price
Description: Mycobacterium Tuberculosis Nitrate reductase-like protein narX (narX), recombinant protein.

Recombinant Pichia pastoris SLX4 Protein (aa 1-652)
VAng-Cr6677-inquire	Creative Biolabs	inquire	Ask for price
Description: Pichia pastoris (strain GS115 / ATCC 20864) Structure-specific endonuclease subunit SLX4 (SLX4), recombinant protein.

Recombinant Streptococcus Pneumoniae aliB Protein (aa 1-652)
VAng-Cr7767-inquire	Creative Biolabs	inquire	Ask for price
Description: Streptococcus Pneumoniae Oligopeptide-binding protein AliB (aliB), recombinant protein.

Recombinant Streptococcus Pneumoniae ftsH Protein (aa 1-652)
VAng-Cr7814-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3198
Description: Streptococcus Pneumoniae ATP-dependent zinc metalloprotease FtsH (ftsH), recombinant protein.

Recombinant Clostridium Perfringens tetP Protein (aa 1-652)
VAng-Lsx00882-inquire	Creative Biolabs	inquire	Ask for price
Description: Clostridium Perfringens Tetracycline resistance protein tetP, recombinant protein.

Recombinant Human ERBB2 Protein (aa 1-652) [AVI]
VAng-Cr3983-inquire	Creative Biolabs	inquire	Ask for price
Description: Recombinant Human ERBB2 Protein (Met1-Thr652) fused with a AVI tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 72.6 kDa. (Accession ID: NP_004439.2)

Recombinant Rhesus ERBB2 Protein (aa 1-652) [Fc]
VAng-Cr3985-100g	Creative Biolabs	100 µg	EUR 1687
Description: Recombinant Rhesus ERBB2 Protein (Met 1-Thr 652) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 96.3 kDa. (Accession ID: XP_001090430.1)

Recombinant Rhesus ERBB2 Protein (aa 1-652) [Fc]
VAng-Cr3985-50g	Creative Biolabs	50 µg	EUR 1027
Description: Recombinant Rhesus ERBB2 Protein (Met 1-Thr 652) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 96.3 kDa. (Accession ID: XP_001090430.1)

Recombinant Human ERBB2 Protein (aa 1-652) [Fc]
VAng-Cr3987-100g	Creative Biolabs	100 µg	EUR 1687
Description: Recombinant Human ERBB2 Protein (Met 1-Thr 652) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 96.1 kDa. (Accession ID: NP_004439.2)

Recombinant Human ERBB2 Protein (aa 1-652) [Fc]
VAng-Cr3987-50g	Creative Biolabs	50 µg	EUR 1027
Description: Recombinant Human ERBB2 Protein (Met 1-Thr 652) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 96.1 kDa. (Accession ID: NP_004439.2)

Recombinant Mouse ErbB4 Protein (aa 1-652) [His]
VAng-Cr3997-100g	Creative Biolabs	100 µg	EUR 1687
Description: Recombinant Mouse ErbB4 Protein (Met1-Leu652) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 71.5 kDa. (Accession ID: Q99P91)

Recombinant Mouse ErbB4 Protein (aa 1-652) [His]
VAng-Cr3997-50g	Creative Biolabs	50 µg	EUR 1027
Description: Recombinant Mouse ErbB4 Protein (Met1-Leu652) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 71.5 kDa. (Accession ID: Q99P91)

Recombinant Schizosaccharomyces Pombe ssp1 Protein (aa 1-652)
VAng-Yyj6250-inquire	Creative Biolabs	inquire	Ask for price
Description: Schizosaccharomyces Pombe (strain 972 / ATCC 24843) (Fission yeast) Serine/threonine-protein kinase ssp1 (ssp1), recombinant protein.

Human Zinc finger protein 652, ZNF652 ELISA KIT
ELI-51280h	Lifescience Market	96 Tests	EUR 824

Mouse Zinc finger protein 652, Znf652 ELISA KIT
ELI-51588m	Lifescience Market	96 Tests	EUR 865

Human pre-microRNA Expression Construct Lenti-miR-652
PMIRH652AA-1	SBI	Bacterial Streak	EUR 684

Human pre-microRNA Expression Construct Lenti-miR-652
PMIRH652PA-1	SBI	Bacterial Streak	EUR 684

Rabbit Anti-Human AR (aa 648-652) Polyclonal Antibody
CPB-1013RH	Creative Diagnostics	100 ul	EUR 460

Biotinylated Human Her2 Protein (Thr 23-Thr 652) [His]
VAng-1611Lsx-200g	Creative Biolabs	200 µg	EUR 3830
Description: Biotinylated Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: AAA75493)

Biotinylated Human Her2 Protein (Thr 23-Thr 652) [His]
VAng-1611Lsx-25g	Creative Biolabs	25 µg	EUR 928
Description: Biotinylated Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: AAA75493)

Cynomolgus Her2 Protein (Thr 23-Thr 652) [His] [Avi]
VAng-1655Lsx-200g	Creative Biolabs	200 µg	EUR 3844
Description: Biotinylated Cynomolgus Her2, Hia tag and Avi tag, is expressed in human 293 cells. (Uniprot ID: XP_005584091.2)

Cynomolgus Her2 Protein (Thr 23-Thr 652) [His] [Avi]
VAng-1655Lsx-25g	Creative Biolabs	25 µg	EUR 1013
Description: Biotinylated Cynomolgus Her2, Hia tag and Avi tag, is expressed in human 293 cells. (Uniprot ID: XP_005584091.2)

Human Her2 Protein (Thr 23-Thr 652) [His] [Avi]
VAng-1714Lsx-200g	Creative Biolabs	200 µg	EUR 3844
Description: Biotinylated Human Her2, His tag and Avi tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

Human Her2 Protein (Thr 23-Thr 652) [His] [Avi]
VAng-1714Lsx-25g	Creative Biolabs	25 µg	EUR 1013
Description: Biotinylated Human Her2, His tag and Avi tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

FITC-Labeled Human Her2 Protein (Thr 23-Thr 652) [His]
VAng-1665Lsx-200g	Creative Biolabs	200 µg	EUR 5219
Description: FITC-Labeled Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

FITC-Labeled Human Her2 Protein (Thr 23-Thr 652) [His]
VAng-1665Lsx-25g	Creative Biolabs	25 µg	EUR 848
Description: FITC-Labeled Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

Recombinant Yersinia Enterocolitica acs Protein (aa 1-652) (strain 8081)
VAng-Wyb1361-inquire	Creative Biolabs	inquire	Ask for price
Description: Yersinia Enterocolitica serotype O:8 / biotype 1B (strain 8081) Acetyl-coenzyme A synthetase, recombinant protein.

Rabbit Anti-human Her2/Erbb2/Neu (1-652) protein IgG
HER32-A	Alpha Diagnostics	100 ul	EUR 482

Anti-ACVR2B (Bimagrumab)-MC-MMAF ADC
ADC-W-652	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-ACVR2B monoclonal antibody conjugated via a MC linker to MMAF

Anti-Hu CD90 APC
1A-652-T025	ExBio	25 tests	EUR 140

Anti-Hu CD90 APC
1A-652-T100	ExBio	100 tests	EUR 240

Anti-Hu CD90 FITC
1F-652-T025	ExBio	25 tests	EUR 122

Anti-Hu CD90 FITC
1F-652-T100	ExBio	100 tests	EUR 204

Anti-Hu CD90 PE
1P-652-T025	ExBio	25 tests	EUR 140

Anti-Hu CD90 PE
1P-652-T100	ExBio	100 tests	EUR 240

Anti-Hu CD90 Purified Azide Free
10-652-C025	ExBio	0.025 mg	EUR 99

Anti-Hu CD90 Purified Azide Free
10-652-C100	ExBio	0.1 mg	EUR 158

Anti-Hu CD90 APC-Cy7
T4-652-T100	ExBio	100 tests	EUR 268

Anti-Hu CD90 PE-Cy5
T8-652-T025	ExBio	25 tests	EUR 140

Anti-Hu CD90 PE-Cy5
T8-652-T100	ExBio	100 tests	EUR 240

Rabbit mono anti-human Her2/Erbb2/Neu (1-652) protein IgG
HER31-M	Alpha Diagnostics	100 ul	EUR 482

Rabbit Anti-monkey/rhesus Her2/Erbb2/Neu (1-652) protein IgG
HER34-A	Alpha Diagnostics	100 ul	EUR 482

Recombinant (HEK) human Her2/Erbb2/Neu (1-652)-hIgG-Fc fusion protein
HER21-R-10	Alpha Diagnostics	10 ug	EUR 408

Recombinant (HEK) human Her2/Erbb2/Neu (23-652)-His-tag fusion protein
HER23-R-10	Alpha Diagnostics	10 ug	EUR 408

Mouse mono anti-monkey/rhesus Her2/Erbb2/Neu (1-652) protein IgG
HER33-M	Alpha Diagnostics	100 ul	EUR 482

Recombinant (HEK) monkey/rhesus Her2/Erbb2/Neu (1-652)-His-tag fusion protein
HER29-R-10	Alpha Diagnostics	10 ug	EUR 408

Recombinant (HEK) monkey/rhesus Her2/Erbb2/Neu (1-652)-hIgG1-Fc fusion protein
HER30-R-10	Alpha Diagnostics	10 ug	EUR 408

Recombinant (HEK) human Her2/Erbb2/Neu (1-652)-Flag tag (DDDDK) fusion protein
HER36-R-10	Alpha Diagnostics	10 ug	EUR 408

Recombinant (HEK) human Her2/Erbb2/Neu (1-652)-Flag tag (DDDDK) fusion protein
HER36-R-50	Alpha Diagnostics	50 ug	EUR 1207

These findings indicate a shifting epidemiology of arboviral disease in West Africa and highlight a need for increased research and implementation of vector and disease control. Rapid urbanization and climate change may further alter disease patterns, underscoring the need for improved diagnostic capacity, and vector and disease surveillance to address this evolving health challenge.