In recent months, various public health measures have been implemented throughout the world in response to the coronavirus disease 2019 (COVID-19) pandemic. This outbreak, and the subsequent containment policies, may have a range of potential short- and long-term impacts on the monitoring and surveillance of other conditions, such as birth defects. In this commentary, we provide a perspective on these potential impacts on birth defects surveillance and analysis.
We discuss possible effects on clinical birth defect diagnoses, routine birth defects surveillance system activities, and epidemiologic considerations, as well as opportunities for mitigating the impact of COVID-19. Like many other sectors of public health and medicine, birth defects surveillance programs may be faced with organizational and methodological obstacles in the wake of a changing landscape.
miRZip-661 anti-miR-661 microRNA construct |
MZIP661-PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
hsa-miR-661 Primers |
MPH01964 |
ABM |
150 ul / 10 uM |
EUR 121 |
p24-HIV(p24/661) Antibody |
BNCA0661-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against p24-HIV(p24/661), APC conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCAP0661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCAP0661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC810661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC810661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC880661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC880661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCB0661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCB0661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC550661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC550661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC430661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC430661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC470661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC470661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC940661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC940661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCP0661-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against p24-HIV(p24/661), PerCP conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC040661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC040661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC050661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC050661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCR0661-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against p24-HIV(p24/661), RPE conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNUB0661-100 |
Biotium |
100uL |
EUR 209 |
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL |
p24-HIV(p24/661) Antibody |
BNUB0661-500 |
Biotium |
500uL |
EUR 458 |
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL |
p24-HIV(p24/661) Antibody |
BNC680661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC680661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC700661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC700661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC400661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC400661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC610661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC610661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC800661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNC800661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCH0661-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNCH0661-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
p24-HIV(p24/661) Antibody |
BNUM0661-50 |
Biotium |
50uL |
EUR 395 |
Description: Primary antibody against p24-HIV(p24/661), 1mg/mL |
hsa-miR-661 miRNA Inhibitor |
MIH03370 |
ABM |
2 x 5.0 nmol |
EUR 176 |
hsa-miR-661 miRNA Antagomir |
MNH03370 |
ABM |
2 x 5.0 nmol |
EUR 329 |
Recombinant (E.Coli) Protein Kinase A Inactive holoenzyme type 1 alpha |
RP-661 |
Alpha Diagnostics |
1 ug |
EUR 164 |
Tigar Recombinant Protein |
40-661 |
ProSci |
5 ug |
EUR 259.25 |
Description: TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Recombinant Human TIGAR expressed in E. coli is a 29.9 kDa protein containing 269 amino acid residues. |
15-PGDH Recombinant Protein |
91-661 |
ProSci |
0.05 mg |
EUR 710.75 |
Description: 15-hydroxyprostaglandin dehydrogenase [NAD(+)], also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. |
IL-22 Recombinant Protein |
92-661 |
ProSci |
0.05 mg |
EUR 684.5 |
Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A. |
MAP Kinase Substrate; EGF-R (661-681) |
5-01501 |
CHI Scientific |
4 x 1mg |
Ask for price |
Polyclonal MYOM2 / Myomesin 2 Antibody (aa612-661) |
APR03243G |
Leading Biology |
0.05ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYOM2 / Myomesin 2 (aa612-661). This antibody is tested and proven to work in the following applications: |
Recombinant Treponema Pallidum tkt Protein (aa 1-661) |
VAng-Cr0963-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Treponema Pallidum (strain Nichols) transketolase (tkt), recombinant protein. |
Recombinant Mycobacterium Tuberculosis Rv0102 Protein (aa 1-661) |
VAng-Yyj0176-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 6731 |
Description: Mycobacterium Tuberculosis Uncharacterized protein Rv0102/MT0111 (Rv0102, MT0111), recombinant protein. |
Recombinant Brucella Abortus bhuA Protein (aa 1-661) |
VAng-Lsx5157-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Brucella Abortus biovar 1 (strain 9-941) Heme transporter BhuA, recombinant protein. |
Recombinant Brucella Suis bhuA Protein (aa 1-661) |
VAng-Lsx5721-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Brucella Suis biovar 1 (strain 1330) Heme transporter BhuA, recombinant protein. |
Recombinant Clostridium Difficile fbp Protein (aa 1-661) |
VAng-Lsx9156-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Clostridium Difficile (strain 630) Fructose-1,6-bisphosphatase class 3, recombinant protein. |
Recombinant Clostridium Tetani uvrB Protein (aa 1-661) |
VAng-Lsx01835-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Clostridium Tetani UvrABC system protein B, recombinant protein. |
Recombinant Pichia pastoris SNX4 Protein (aa 1-661) |
VAng-Cr6678-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Pichia pastoris Sorting nexin-4 (SNX4), recombinant protein. |
Human pre-microRNA Expression Construct Lenti-miR-661 |
PMIRH661PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
Recombinant HCV-1c E2 Protein (aa 384-661) [His] |
VAng-Wyb7362-100g |
Creative Biolabs |
100 µg |
EUR 1747 |
Description: Hepatitis C virus (serotype 1c,isolate HC-G9) E2 protein, recombinant protein. |
Recombinant HCV-1c E2 Protein (aa 384-661) [His] |
VAng-Wyb7362-20g |
Creative Biolabs |
20 µg |
EUR 679 |
Description: Hepatitis C virus (serotype 1c,isolate HC-G9) E2 protein, recombinant protein. |
Recombinant HCV-1c E2 Protein (aa 384-661) [His] |
VAng-Wyb7362-50g |
Creative Biolabs |
50 µg |
EUR 1213 |
Description: Hepatitis C virus (serotype 1c,isolate HC-G9) E2 protein, recombinant protein. |
Recombinant Trypanosoma Brucei HSP70-4 Protein (aa 1-661) |
VAng-Wyb8104-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Trypanosoma Brucei brucei Heat shock 70 kDa protein 4, partial, recombinant protein. |
Recombinant Caenorhabditis Elegans lst-2 Protein (aa 1-661) |
VAng-Ly3528-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Caenorhabditis Elegans lateral signaling target protein 2 (lst-2), partial, recombination protein. |
HIV type 1 Glycoprotein 140 (aa 37 - 661)(Du151) [His] |
DAG2131 |
Creative Diagnostics |
100 µg |
Ask for price |
Recombinant Brucella Abortus bhuA Protein (strain 2308) (aa 1-661) |
VAng-Lsx4953-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Brucella Abortus (strain 2308) Heme transporter BhuA, recombinant protein. |
Anti-AFP (Tacatuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC |
ADC-W-661 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-AFP monoclonal antibody conjugated via a MC-Vc-PAB-DMEA-(PEG2) linker to duocarmycin SA |
Anti-Hu CD84 APC |
1A-661-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-Hu CD84 APC |
1A-661-T100 |
ExBio |
100 tests |
EUR 240 |
Anti-Hu CD84 FITC |
1F-661-T025 |
ExBio |
25 tests |
EUR 122 |
Anti-Hu CD84 FITC |
1F-661-T100 |
ExBio |
100 tests |
EUR 204 |
Anti-Hu CD84 PE |
1P-661-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-Hu CD84 PE |
1P-661-T100 |
ExBio |
100 tests |
EUR 240 |
Anti-Hu CD84 Purified |
11-661-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-Hu CD84 Purified |
11-661-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-Hu CD84 Purified Low Endotoxin |
12-661-C100 |
ExBio |
0.1 mg |
EUR 158 |
MAP Kinase Substrate; EGF-R (661-681) (AA: Lys-Arg-Glu-Leu-Val-Glu-Pro-Leu-Thr-Pro-Ser-Gly-Glu-Ala-Pro-Asn-Gln-Ala-Leu-Leu-Arg) (MW: 2318.66) |
SP-101475-1 |
Alpha Diagnostics |
1 mg |
EUR 164 |
A better understanding of these potential challenges faced by birth defects surveillance programs could facilitate better planning and collaboration across programs to overcome barriers to core activities and to prepare for novel opportunities for research and prevention.